The high resistance to ciprofloxacin, a critically important fluoroquinolone antimicrobial for treatment of Salmonella and Campylobacter infections, is a growing concern. Resistance to ciprofloxacin was found to be increasing in Salmonella Enteritidis and Campylobacter jejuni from humans in over half of the European countries that submitted data. High to extremely high proportions of ciprofloxacin resistance have been observed in Campylobacter from food-producing animals, and in Salmonella and E. coli from poultry specifically. These trends are particularly worrying as the 2024 World Health Organization list of harmful bacteria classifies fluoroquinolone-resistant non-typhoidal Salmonella (Salmonella serotypes that do not cause typhoid fever) as a high priority.
In contrast, resistance to other critically important antimicrobials used in human medicine remains uncommon for Salmonella and Campylobacter, both for humans and food-producing animals.
Although carbapenem resistance remains rare, the occasional detection of carbapenem resistant E. coli in food and animals calls for sustained vigilance and further epidemiological investigations. This is especially important because carbapenem-resistant Enterobacterales bacteria are recognised as a critical threat to public health. To support this effort, in 2025 EFSA will publish the first in a series of opinions on the current status of the occurrence The fact or frequency of something (e.g. a disease or deficiency in a population) happening and spread of carbapenemase-producing Enterobacterales in the food chain in the European Union/European Economic Area and Switzerland.
However, there are also positive trends, with data revealing significant progress in reducing resistance levels in several reporting countries. Nearly half of the European countries that submitted data indicated a decline in resistance of Campylobacter to macrolide antibiotics, in both C. jejuni and C. coli, in human cases. Furthermore, resistance of Salmonella Typhimurium isolates from humans to penicillins and tetracyclines has decreased over time. The significant increasing trends in the key outcome indicator for complete susceptibility ‘Complete susceptibility’ or ‘zero resistance’ – is technically defined as susceptibility to all antimicrobial groups included in harmonised panels of antimicrobials addressed within the framework of a monitoring of E. coli, as well as the significant decreasing trends in the key outcome indicator for prevalence The proportion of a population found to have a condition of ESBL-/AmpC-producing E. coli show that there has been encouraging progress in reducing AMR in food-producing animals in several EU Member States over the last 10 years.
Despite some improvements, antimicrobial resistance The ability of microbes to grow in the presence of substances specifically designed to kill them; for example, some human infections are now resistant to antibiotics, raising concerns about their widespread use remains a major public health threat that requires coordinated action with a One-Health approach. Key measures include promoting the responsible use of antimicrobials, improving infection prevention and control, investing in research for new treatments, and implementing strong national policies to combat resistance effectively.
EFSA and ECDC are publishing a plain language summary — a simplified version of the EU summary report on antimicrobial resistance in zoonotic A term given to diseases and infections that can be transmitted between animals and humans and indicator bacteria from humans, animals and food in 2022–2023 — along with several interactive communication tools.
An interactive data visualisation tool shows resistance levels in humans, animals and food, country-by-country in 2022 and 2023.
O artigo foi publicado originalmente em EFSA.